Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates

The brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life. As a result of the blood brain barrier, it is difficult to deliver drugs to the brain. Brain targeting drug delivery systems are one solution to improving the treatment of CNS disorders. In recent decades, knowledge about the brain and CNS disorders has increased significantly. CNS disorders and brain targeting drug delivery systems have attracted increased attention. Brain Targeted Drug Delivery Systems focuses on nanotechnology and nanoparticulates, and provides a guide to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems.

Provides an overview of brain targeting drug delivery useful to both academic and industry-based researchersDiscusses key points in developing brain targeting drug delivery systemsSummarizes and presents current available strategies for brain targeting drug deliveryCovers not only current studies and their strengths, but also gives insight into the pitfalls of current researchLooks into the future direction of the whole area

1. Introduction and overview

Part I Physiology and principles for brain targeting drug delivery

2. Anatomy and physiology of blood-brain barrier

3. Recent progress in blood-brain barrier transportation research

4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery

Part II Nanoparticles-based brain targeting delivery strategies

5. Receptor-mediated transportation through BBB

6. Carrier-mediated transportation through BBB

7. Brain drug delivery by adsorption-mediated transcytosis

8. Efflux pump inhibition to enhance brain targeting delivery

9. Physically open BBB

10. Nanoparticle systems for nose-to-brain delivery

11. Brain local delivery strategy

Part III Nanoparticles-based brain targeting delivery for CNS disorder management

12.Glioma targeted delivery systems

13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases

14. Savaging brain ischemia by increasing brain uptake of neuroprotectants

Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery

15. Neurotoxicity concern about the brain targeting delivery systems

16. The intra-brain distribution of brain targeting delivery systems

17. The elimination of brain-targeted nanomaterials

18. Perspective on brain targeting drug delivery systems