Nervous System Drug Delivery: Principles and Practice

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

Offers an up-to-date, comprehensive resource on drug delivery to the nervous systemProvides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application)Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

Section I. Physiology of Nervous System Drug Delivery 1. Fundamentals of Brain–Barrier Anatomy and Global Functions 2. Blood-Brain Barrier in Disease States 3. Pharmacokinetics of Systemic Drug Delivery 4. Pharmacokinetics of Drug Delivery Past the Blood-Brain Barrier 5. Anatomy and Physiology of Cerebrospinal fluid Dynamics 6. Pharmacokinetics of Polymeric Drug Delivery 7. Pharmacokinetic Models of Convection-Enhanced Drug Delivery 8. Mechanisms and Clinical Applications of Stem Cell Therapy

Section II. Nervous System Drug Delivery Techniques 9. Intravenous and Intravascular Drug Delivery 10. Blood-Brain Barrier Disruption 11. Ultrasonic Methods 12. Nanoparticles for Brain Tumor Delivery 13. Solute Transport in the Cerebrospinal Fluid: Physiology and Practical Implications 14. Drug-impregnated Polymer Delivery  15. Immunomodulatory Methods 16. Convection-Enhanced Drug Delivery in the Central Nervous System 17. Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices 18. CRISPR–Cas Gene Editing for Neurological Disease

Section III. Clinical Application of Nervous System Drug Delivery 19. Drug and Disease-Specific Paradigms for Drug Delivery to the Central Nervous System 20. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Brain Tumors 21. Clinical Methods of Nervous System Drug Delivery for Tumors 22. Delivery Methods for Treatment of Genetic Disorders 23. Direct Convective of Nervous System Drug Delivery for Patients with Neurodegenerative Disorders 24. Central Nervous System Drug Delivery after Ischemic or Hemorrhagic Stroke 25. Intrathecal Drug Delivery for Cancer Pain