Emerging Technologies for Heart Diseases: Volume 2: Treatments for Myocardial Ischemia and Arrhythmias

The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation.

Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas.

Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implicationsWritten by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promiseChapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with myocardial ischemia and arrhythmias

SECTION 5: Treatment of ischemic heart disease 24. Coronary Balloon Angioplasty, Stenting, and Bioabsorbable Scaffolds 25. Coronary thrombectomy 26. Coronary atherectomy and treatments for calcified coronary lesions 27. Treatment of chronic total occlusion 28. Minimally-invasive device-based approaches for improving cardiac perfusion 29. Gene therapy approaches to cardiac neovascularization and protection from ischemia

SECTION 6: Treatment and prevention of ventricular tachyarrhythmias 30. The past, present and future of implantable electrical defibrillators 31. Electrophysiological mapping and cardiac ablation therapy for the prevention of ventricular arrhythmias 32. Gene and cell therapy approaches for the prevention and treatment of ventricular arrhythmia

SECTION 7: Treatment and prevention of supraventricular tachyarrhythmias 33. Ablation therapy and implantable device-based approaches for supraventricular arrhythmias 34. Gene and cell-based therapies for the prevention and treatment of supraventricular arrhythmias

SECTION 8: Treatment and prevention of bradyarrhythmias 35. Cardiac rhythm devices of today and tomorrow 36. Molecular therapies for bradyarrhythmias 37. Cell therapy approaches for treatment of bradyarrhythmias 38. Optogenetics for cardiac pacing and termination of arrhythmias 39. Non-optognetic approaches for leadless cardiac pacing

SECTION 9: Flexible electronics for cardiac monitoring and therapy 40. Organ Conformal Electronics for Cardiac Therapeutics

SECTION 10: Device-based therapies for prevention of cerebral embolization 41. Embolic protection devices for stroke prevention during cardiac interventions 42. Percutaneous closure of the left atrial appendage for stroke prevention 43. Devices for continuous embolic protection

SECTION 11: Noninvasive methods for structural heart defects 44. Transcatheter closure of atrial septal defect in adults 45. Catheter-based treatments for ventricular septal defects

SECTION 12: Novel treatments for hypertension 46. Non-pharmacological therapies for uncontrolled hypertension