An Introduction to Interdisciplinary Toxicology: From Molecules to Man

An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from “simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included.

The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.

Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicityIncludes a variety of perspectives to give a complete understanding of toxicologyWritten by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained

I. General Concepts 1. Principles 2. Sources of exposures: Point vs Nonpoint Source Contamination 3. How chemicals distribute in the physical environment 4. How chemicals distribute in cells and simple organisms 5. How chemicals distribute in complex organisms

II. Responses to chemical toxicants 6. Cellular responses to toxicants 7. Genotoxicity and epigenetics 8. Carcinogenesis 9. Disruption of cell signaling 10. Altered development and reproduction 11. Microbiome alterations and modulation of toxicity 12. Nanotoxicology

III. Organ System Effects 13. Dermal system 14. Gastrointestinal system 15. Excretory system 16. Respiratory System 17. Cardiovascular system 18. Musculoskeletal system 19. Endocrine system 20. The immune system 21. Visual system 22. Nervous system

IV. Ecosystems and Ecotoxicology 23. Organism vs population 24. Bioconcentration 25. Biomarkers

V. Toxicology in the Home 26. Opiates and other therapeutics 27. Cleaning products 28. Petroleum products

VI. Toxicology in the Community 29. Historical case studies 30. Social factors in community contamination

VII. Forensic Toxicology

VIII. Regulatory Toxicology 31. Toxicity testing 32. Tox21 33. Principles of Risk Assessment

IX. Reference materials and websites 34. Information Resources in Toxicology, 4th edition. 35. National Toxicology Program 36. National Center for Toxicological Research 37. FDA 38. EPA