Introductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.

Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and diseasePresents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topicsIdeal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

1. Early Sirtuin Research 1991-2000 2. Regulation of sirtuins by systemic NAD+ biosynthesis 3. NAD modulation - biology and therapy 4. The enzymatic activity of sirtuins 5. Molecular mechanisms of Sirtuin activation and inhibition 6. Pharmacological approaches for modulating sirtuins 7. Mitochondrial Sirtuins 8. Biological Roles and Activities for Mitochondrial Sirtuins 9. The multitasking roles of the mammalian deacetylase SIRT6 10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond 11. Sirtiuns and Carcinogenesis 12. Roles for sirtuins in cardiovascular biology 13. Sirtuins in Brain Biology and Disease