Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, it highlights the need for implementation of the principles of precision medicine into the management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient.

Written for basic researchers and medical doctors, this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice.

Bridges the gap between precision medicine research and the implementation of the principles into and daily clinical practiceIncludes contributions from key opinion leaders in the field of airway disease for a worldwide perspectiveDiscusses precision medicine in terms of personalized medicine, prediction of success, participation of the patient and prevention of disease

Part I The Concept of Precision Medicine and Precision Health 1. The Audacious Goal of Precision Medicine 2. Critical Entry Points—Genetics and Epigenetics 3. Critical Entry Points—Microbiome 4. Factors Modulating the Disease Endotype 5. Revised Disease Nomenclature Including Disease Endotypes

Part II Shortcomings of Current Care Pathways for Chronic Airways Diseases 6. The Global Burden of Chronic Airway Diseases 7. Unmet Needs in Chronic Upper Respiratory

Part III Personalized Care: Endotype-driven Treatment 8. Endotype-Driven Approach for Asthma 9. Endotype-Driven Approach for Chronic Rhinosinusitis 10. Endotype-Driven Approach in Rhinitis 11. Prevention of Allergies 12. Prevention of Asthma 13. Prevention of Chronic Rhinosinusitis 14. Current and Future Biomarkers for Allergy and Asthma 15. Validation and Qualification of Biomarkers and Their Translation Into Pathway-Specific Diagnostic Tests 16. Critical Issues for the Endotype/Biomarkers Approach 17. Key Points for Moving the Endotypes Field Forward

Part IV Health Information Technology and PM 18. Telemedicine and Mobile Health Technology in the Diagnosis, Monitoring and Treatment of Respiratory Allergies 19. Real-Time Clinical Decision Support at the Point of Care 20. Patient-Friendly HIT Tools and the Advent of Crowdsourcing Clinical Trials

Part V Participation of the Patient 21. The Patient-Centered Decision System as per the 4Ps of PRECISION MEDICINE 22. Interpersonal Dimensions of Personalized Medicine for Chronic Obstructive Pulmonary Disease

Part VI Bringing Precision Medicine to the Clinic 23. Big Data Translation Into Clinical Decision Algorithms 24. European Union Funding of Research on Airway Diseases 25. Provision of Care - Implementation of the Finnish Allergy Programme 2008-2018 26. Improving Understanding and Common Usage of Disease Phenotypes, Endotypes, Biomarkers and Precision Therapies at the Point of Care 27. Full Patient Monitoring Using Digital Health Technology 28. Global Multidisciplinary Networks 29. EUFOREA Approach to Precision Medicine in Respiratory Diseases