Modeling and Control of Infectious Diseases in the Host: With MATLAB and R

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R.

Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseasesIncludes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phasesPresents a theoretic approach to schedule drug treatments

Part 1. Theoretical Biology Principles 1. Introduction 2. Mathematical Modeling Principles 3. Model Parameter Estimation

Part 2. Modeling Host Infectious Diseases 4. Modeling Influenza Virus Infection 5. Modeling Ebola Virus Infection 6. Modeling HIV Infection 7. HIV Evolution During Treatment

Part 3. Advanced Topics in Control Theory 8. Optimal Therapy Scheduling 9. Suboptimal Therapy Scheduling 10. PK/PD-based Impulsive Control