Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.

Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articlesCombines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncologyDelves into unanswered questions and future directions of this important blood-clotting complex

1. Historical Background 2. Factor VIII: Anatomy and Physiology 3. Genetic Basis of Hemophilia 4. Factor VIII Therapy for Bleeding 5. Complications of Therapy 6. Acquired Disorders of Factor VIII 7. Factor VIII and Thrombosis 8. Factor VIII: Future Directions