Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Overview of Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Tourette’s syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually.

This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers.

By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.

Presents the first comprehensive, tabulated summary of literature on the epidemiological data on smoking and neurological diseaseIncludes preclinical and clinical data on nicotine in neurological diseases and mechanisms of action of nicotine in neuroprotectionFeatures a comprehensive summary of non-nicotine smoke constituents with potentially neuroprotective and anti-inflammatory propertiesDiscusses Multiple Sclerosis, Alzheimer’s disease, Parkinson’s Disease, Schizophrenia, Depression, ADHD, Anxiety and Tourette’s Syndrome in the context of smoking and nicotine

1. Multiple sclerosis 2. Parkinson’s disease 3. Alzheimer's disease 4. Tourette syndrome 5. Attention Deficit Hyperactivity Disorder in children and adults 6. Schizophrenia 7. Depression 8. Anxiety 9. Active principles from tobacco or smoke 10. Animal and cellular models of MS, AD and PD and major consideration for translatability 11. Conclusion remarks 12. References