Molecular Approach to Cancer Management

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials.

This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.

Covers all relevant topics with a defined aim of targeted therapyEncompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cellsDirects attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

1. Modulation of growth factor signaling in targeted therapy: Role of the epidermal growth factor family and their receptors 2. The TGF-B family accessory type III receptor function in cancer progression 3. Insulin-like growth factor signaling as a target to control tumor progression 4. Angiogenesis in neoplasia and antiangiogenesis strategy in the control of tumor growth and metastasis 5. On the trail of TRAIL in tumor growth and angiogenesis 6. Hedgehog (Hh) signaling in EMT, CSCs and angiogenesis 7. Hedgehog is involved in angiogenic signaling by angiopoietin-1 8. Hippo signaling in cell proliferation, migration and angiogenesis 9. Tumor suppression and inhibition of angiogenesis by TXNIP 10. Suramin and polysulphonated naphthylureas as angiogenesis inhibitors 11. Quercetin inhibits growth factor signaling: suppresses angiogenesis and cell migration in vitro 12. Selenoproteins in cancer control 13. Inhibitor of DNA binding proteins in angiogenesis 14. Are there gains to be made in exploring anthrax lethal toxin (LeTx) as a tumor and an angiogenesis inhibitor? 15. Small molecule inhibitors of angiogenesis and cell proliferation 16. Control of tumor growth and angiogenesis by thalidomide and its analogues 17. Endogenous inhibitors of angiogenesis 18. Metformin and its antitumor attributes 19. Statins in cancer biology 20. The HMG (High mobility group) proteins in cancer progression 21. MTAs in EMT activation and tumor and metastasis promotion 22. S100A4 has potential benefits as a therapeutic target 23. Notch Signaling in carcinogenesis 24. Canonical and non-canonical activation of NF-κB in tumorigenesis 25. Stem cells in cancer therapy 26. Notable approaches to cancer immunotherapy