Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation, Second Edition: Models in Discovery and Translation provides clinical and scientific researchers with a deep understanding of the current research in this field and its implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success.

Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance prospects for the future. New sections focus on microbiome, metabolism, micro-RNA and mRNA regulatory mechanisms and pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies and immune system engagers for GVHD and graft-vs-tumor (GVT), and hematopoietic cell transplant for tolerance induction in solid organ grafts.

Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to bedsideGuides readers through the caveats that must be considered when drawing conclusions from studies with animal models Categorizes published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

1. Overview 2. HLA system 3. Minor Ag 4. In vivo imaging 5. Engraftment, graft rejection and graft failure 6. Immune regeneration or immune recovery 7. Tumor associated antigens 8. Genetically engineered T cell therapies and immune system engagers for GVHD and GvL 9. Microbiome 10. micro-RNA and kinase regulatory mechanisms and pathways in GVHD 11. Costimulation vs. Inhibition 12. Th1/2 and TC1/2 13. Treg 14. Th17 15. B and T cells in chronic GVHD 16. NK 17. Cytokines 18. Chemokines 19. Metabolism and intracellular sensor 20. Omics 21. Endothelium and stroma 22. Future