Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as the challenge of integrating epigenetics into pharmacogenomics research, pharmacoeconomics, cost-effectiveness and reimbursement. The issue of ethnicity and ethno-bridging in translating and implementing scientific findings worldwide is also discussed. With chapters written by interdisciplinary experts and containing insight into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation.

Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomicsThis new edition highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience and challenges, and perspectives on direct-to-consumer genetic testingIncludes discussion points and review questions along with clinical pearls or cases for self-assessment purposes or to facilitate in-depth discussion

1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics 3. Incorporating Pharmacogenomics in Drug Development: Industry and Regulatory Perspectives 4. Translating Pharmacogenomic Research to Therapeutic Potentials 5. Pharmacogenomics in Cancer Therapeutics 6. Pharmacogenomics in Cardiovascular Diseases 7. Pharmacogenomics in Psychiatry Disorders 8. Role of Pharmacogenomics in HIV Infection 9. Role of Pharmacogenomics in Diabetes 10. A Look to the Future: Pharmacogenomics, Pharmacoepigenomics, and System Biology - Data Technologies of Today and Tomorrow 11. The Importance of Ethnicity Definitions and Pharmacogenomics in Ethnobridging and Pharmacovigilance 12. Pharmacogenomics in Latin American Population 13. Reactive, Point-of-Care, Pre-emptive and Direct-to-Consumer Pharmacogenomic Testing 14. Economic Evaluation of Pharmacogenomic Testing: Lessons from Psychiatric Pharmacogenomics 15. Pharmacogenomics Education and Clinical Practice Guidelines