Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions

Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practice related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. Cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference bridges the gap between research, up-to-date clinical information, and the technological facets of thrombus formation, diagnosis and management in cardiovascular medicine. The book includes a comprehensive pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends.

It is the perfect reference for basic science researchers and researchers of cardiology, interventional and general cardiologists, interventional and general radiologists, vascular medicine specialists, and vascular and general surgeons.

Provides a comprehensive understanding of the pathophysiology, clinical presentations and diagnosis of cardiovascular thrombosisIncludes the most up-to-date information on the practical management of patients with thrombus related conditionsWritten by the leading experts in the fieldDelivers an explanation of the current and upcoming pharmacotherapy and technology available for thrombus research and treatment

Section 1. Pathology 1. Hemostasis and thrombosis 2. Vascular wall pathology- effect on thrombosis 3. Mechanisms of thrombosis and their relationship to atherosclerosis: Endothelial cell function and injury [trauma, infection] 4. Platelet aggregation in the pathogenesis of vascular ischemia conditions 5. Physical properties and morphologic features of thrombus 6. Pathology of arterial thrombosis 7. Thrombus types 8. The calcified thrombus: histopathology 9. Pathology of venous thrombosis 10. Hypercoagulopathy: acquired syndromes and thrombosis 11. Hypercoagulopathy: hereditary syndromes and thrombosis 12. Intra cardiac thrombosis: ventricles, atria, appendage and valves 13. Prosthetic surgical valves and TAVR thrombosis 14. Closure devices and thrombosis

Section 2. Clinical presentations 15. Thrombotic ischemic syndromes of the coronary circulation 16. Thrombotic ischemic syndromes of the brain 17. Thrombotic syndromes of the peripheral arterial circulation 18. Thrombosis of the splanchnic and mesenteric 19. Unique thrombus-containing lesions 20. Thrombosis of the venous system: DVT; portal vein; renal vein; Superior vena cava; Jugular; Budd-Chiari; cavernous sinus; cerebral 21. The angry thrombus phenomenon and the simultaneous thrombus in different vascular beds 22. Pulmonary embolism-acute 23. Pulmonary embolism: chronic 24. Platelets, thrombus and thrombosis in pregnancy 25. Atrial fibrillation and thromboembolism

Section 3. Diagnosis 26. Cardiovascular Thrombus classifications 27. Laboratory studies of thrombus and thrombosis 28. Imaging modalities

Section 4. Treatment Guidelines 29. The role of treatment guidelines-comparing the US and European approach to cardiovascular thrombus

Section 5. Pharmacotherapy 30. From Coumadin to the new anticoagulation agents 31. Antiplatelet agents: asa; heparins; LMH 32. Direct thrombin inhibitors 33. The 2b/3a receptor antagonists 34. Thienopyridines 35. Thrombolytic agents

Section 6. Interventions 36. Percutaneous approach: 37. Protection filters 38. Mechanical thrombectomy: Angiojet and X-Sizer 39. Stents: dedicated thrombus containing stent platforms 40. Extraction and vaporization devices: thrombocat and laser 41. LAA closure 42. Surgical approach

Section 6. Future trends 43. Pharmacotherapy and technology