Toxicoepigenetics: Core Principles and Applications

Epigenetic Toxicology: Core Principles and Applications examines epigenetics, including chromatin biology, DNA methylation and non-coding RNA, along with fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Epigenetics have taken center stage in the study of diseases, such as cancer, diabetes and neurodegeneration. However, the integration of epigenetics in the field of toxicology is still in its infancy. This book presents unified, practical and easy to follow protocols to help improve their effectiveness and efficiency. In addition, it includes online protocols (as PDFs) to help increase practical applicability and facilitate incorporation of epigenetics into toxicology research programs.

It is an essential book for advanced students and researchers using epigenetics in toxicology research and study.

Presents toxicologists with a broad range of backgrounds with the fundamental principles of epigenetics Discusses the incorporation of epigenetics and epigenomics into current toxicological studiesIncludes basic protocols covering most epigenetic endpoints

1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation 2. The Role of Histone Methylation and Methyltransferases in Gene Regulation 3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility 4. Implications for Chromatin Biology in Toxicology 5. The Role of DNA Methylation in Gene Regulation 6. Implications of DNA Methylation in Toxicology 7. DNA Methylation as a Biomarker in Environmental Epidemiology 8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology 9. The Role of Non-Coding RNAs in Gene Regulation 10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure 11. Germline and Trans-generational Impacts of Toxicant Exposures 12. Novel Bioinformatics Methods for Toxicoepigenetics 13. Incorporating Epigenetics into Risk Assessment Frameworks 14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis 15. Methods for Analysis of DNA Methylation 16. Methods for Analyzing miRNA Expression