Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.

Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignanciesPresents an in-depth treatment of the biological underpinnings of GRP78 and its connection to diseaseProvides four-color illustrations that facilitate the narrative

1. Introduction to the Discovery of the Endoplasmic Reticulum Chaperone GRP78 on the Cell Surface 2. The Endoplasmic Reticulum Chaperone GRP78 also Functions as a Cell Surface Signaling Receptor 3. Cell surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer 4. Cell Surface GRP78: A Targetable Marker of Cancer Stem-like Cells 5. Cell Surface GRP78 Regulates the Pro-Coagulant Activity of Tissue Factor 6. GRP78 Modulates the Plasminogen Activating System in the Brain: Implications for Human Disease 7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 preventing COOH-terminal Signaling