The Handbook of Metabolic Phenotyping

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores the wide array of analytical chemistry and statistical modelling techniques used in the field, also presenting surveys of various application areas in human development, nutrition, disease, therapy and epidemiology. The book covers recent studies that integrate the various -omics datasets to derive a system biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts, the book is a valuable resource for post-grads and research scientists studying and furthering the field of metabolomics.

Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotypingExplores, in detail, the many diverse statistical approaches used in the fieldOffers practical tips for successfully conducting metabolic phenotyping studiesFeatures reviews of all of the various fields of activity relating to human studies

1. An Overview of Metabolic Phenotyping and Its Role in Systems Biology

2. NMR Spectroscopy Methods in Metabolic Phenotyping

3. The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping

4. GC-MS-Based Metabolic Phenotyping

5. Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry

6. Supercritical Fluid Chromatography for Metabolic Phenotyping: Potential and Applications

7. The iKnife: Development and Clinical Applications of Rapid Evaporative Ionization Mass Spectrometry

8. Univariate Statistical Modeling, Multiple Testing Correction, and Visualization in Metabolome-Wide Association Studies

9. Multivariate Statistical Methods for Metabolic Phenotyping

10. Data-Driven Visualizations in Metabolic Phenotyping

11. Big Data and Databases for Metabolic Phenotyping

12. Progress in Standardization of Metabolic Phenotyping Data

13. Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres

14. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development

15. Metabolic Phenotyping in Nutrition Research

16. Metabolic Phenotyping in Clinical Practice

17. Applications of Metabolic Phenotyping in Epidemiology

18. Influence of the Human Gut Microbiome on the Metabolic Phenotype

19. Linking Metabolic Phenotyping and Genomic Information

20. Metabolic Phenotyping: History, Status, and Prospects