Sirtuins in Health and Disease

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins - substrate specificity and inhibitor design, and chemical probes in sirtuin research.

This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research.

1. Chemical Probes in Sirtuin Research Xiao Hu and Weiping Zheng 2. Targeting Sirtuins: Substrate Specificity and Inhibitor Design Nima Rajabi, Iacopo Galleano, Andreas S. Madsen and Christian A. Olsen 3. Regulatory Effects of NAD⁺ Metabolic Pathways on Sirtuin Activity Ning Zhang and Anthony A. Sauve 4. Sirtuins as Modifiers of Huntington’s Disease (HD) Pathology Sin Hui Neo and Bor Luen Tang 5. Mammalian Sirtuins SIRT4 and SIRT7 Shengchao Li and Weiping Zheng