Epigenetics in Human Disease

Epigenetics is one of the fastest growing fields in biomedical research, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. In Epigenetics in Human Disease, Second Edition, leading international researchers examine those diseases or conditions for which we have advanced knowledge of epigenetic mechanisms such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders, and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis, and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and data sets, early-life programming of epigenetics in age-related diseases, and epigenetics of addiction and suicide, as well as epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. With its translational focus, Epigenetics in Human Disease, Second Edition, serves as an invaluable reference for both basic scientists and clinicians alike

Includes contributions by leading international investigators involved in translational epigenetic research and therapeutic applicationsIntegrates methods and applications with fundamental chapters on epigenetics in human disease, as well as evaluation of recent epigenetic clinical breakthroughsSide-by-side coverage of the basis of epigenetic diseases and treatment pathwaysThis new edition has been fully revised to cover current developments in disease epigenetics, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and data sets, early-life programming of epigenetics in age-related diseases, and epigenetics of addiction and suicide, as well as epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies

Section I: Introduction 1. Epigenetics in Human Disease

Section II: Methodology 2. Methods and Strategies to Determine Epigenetic Variation in Human Disease 3. Age Estimates Using DNA Methylation Patterns 4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing

Section III: Human Cancer 5. DNA Methylation Alterations in Human Cancers 6. Alterations of Histone Modifications in Cancer 7. MicroRNA in Cancer 8. Epigenetic Approaches to Cancer Therapy

Section lV: Neurological Disease 9. Epigenomics in Neurobehavioral Disease 10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders 11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease 12. Epigenetic Modulation of Human Neurobiological Disorder

Section V: Autoimmune Disease 13. Epigenetic Basis of Autoimmune Disorders in Humans 14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

Section VI: Metabolic Disorders 15. Epigenomic Factors in Human Obesity 16. Epigenetic Approaches to Control Obesity 17. Epigenetics of Diabetes in Humans 18. The Potential of Epigenetic Compounds in Treating Diabetes

Section VII: Other Disorders/Diseases 19. Epigenetic Aberrations in Human Allergic Diseases 20. Therapy of Airway Disease: Epigenetic Potential 21. The Role of Epigenetics in Cardiovascular Disease 22. Epigenetic Treatment Approaches to Cardiovascular Disease 23. Epigenetics and Human Infectious Diseases 24. Therapy of Infectious Diseases Using Epigenetic Approaches 25. The Epigenetics of Endometriosis 26. Epigenetic DNA Methylation in Endometrial Cancer 27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases

Section VIII: Development, Aging and Transgenerational Effects 28. Epigenetics of Transgenerational Inheritance in Disease 29. Epigenetic Mechanisms of Human Imprinting Disorders 30. Therapeutic Approaches to Imprinting Diseases 31. Stem Cell Epigenetics and Human Disease 32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy 33. Aging and Disease: The Epigenetic Bridge 34. Epigenetic Programming of Human Disease and Aging

Section lV: Future Research 35. Future Directions in the Epigenetics of Human Disease