Neural Mechanisms of Addiction

In recent years, optogenetics and other newly developed techniques have rapidly advanced researchers’ understanding of addiction, particular the basic biology of reinforcement learning that is usurped by abused substances. Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding of the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders - such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms - that are not covered in any other book publication. Neural Mechanisms of Addiction will provide readers with the most up-to-date information to build a foundation for their future research as the field continues to grow and expand. Combining chapters from leading researchers and thought leaders, the book will be an indispensable guide for students and investigators at all levels engaged in addiction researchers.

Transcends multiple neural, neurochemical, and behavioral domainsSummarizes the advances in the field of addiction research since the advent of optogeneticsDiscusses the current leading theories of addiction, including molecular mechanisms and dopamine mechanisms

1. Introduction
Mary M. Torregrossa
2. Animal Models of Addiction
Rita A. Fuchs
3. Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction
A.J. Robison
4. Neural Circuit Alterations in Addiction
Matt Hearing and Eden Marie Anderson
5. Glutamatergic Neuroplasticity in Addiction
L. A. Knackstedt and Allison Bechard
6. Neural Ensemble Encoding of Addictive Behavior
Bruce Hope
7. Interoceptive Stimulus Effects of Drugs of Abuse
Jennifer Murray
8. Maladaptive Memory Mechanisms in Addiction and Relapse
Mary M. Torregrossa
9. Neural Morphology and Addiction
Patrick Mulholland
10. Mechanisms regulating compulsive drug behaviors
David M. Dietz
11. Role of Stress-Associated Signaling in Addiction
John Mantsch and Elizabeth M. Doncheck
12. Negative Reinforcement Mechanisms in Addiction
Olivier George
13. Circadian Rhythms and Addiction
Ryan Logan
14. Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by Stress
Jacqueline McGinty
15. The Role of Norepinephrine in Addiction: Past, Present, and Future
David Weinshenker
16. Glial Dysregulation in Addiction
David Baker
17. Role of the Extracellular Matrix in Addiction
Peter W. Kalivas and Lauren Beloate
18. Striatal cell-type specific plasticity in addiction
Mary Kay Lobo
19. Harnessing Circuits for the Treatment of Addictive Disorders
Christelle Baunez
20. Conclusions and Future Directions
Mary M. Torregrossa