Perinatal Stem Cells: Research and Therapy

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.

In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.

Explores current clinical and pre-clinical application of stem cells derived from perinatal sourcesOffers detailed insight into sources of perinatal stem cells and their potential for disease treatmentDiscusses progress in the manufacturing, banking and clinical translation of perinatal stem cellsEdited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Section I. Amniotic Fluid-Derived Stem Cells

1. In utero therapy for congenital disorders using amniotic fluid stem cells

2. The Amniotic Fluid Stem Cell Secretome: at the Heart of Regeneration

3. Transplantation of Amniotic Fluid-Derived Neural Stem Cells

4. Stroke therapy: the potential of amniotic fluid-derived stem cells

5. Vascular formation by human perinatal stem cells

6. Amniotic Fluid Stem Cells for Kidney Regeneration

Section II. Placental and Placental Membrane-Derived Stem Cells

7. Placental mesenchymal stem cells for cellular cardiomyoplasty

8. Heterogeneous functions of perinatal mesenchymal stromal cells require a preselection before their banking for clinical use

9. Defining the fetal stem cell niche in the human placenta

10. Banking placental tissue hematopoietic stem cells and mesenchymal stem cells for clinical use

11. Immuno-modulatory mechanisms of placental stem cells

12. Amnion Membrane Allograft for Regenerative Medicine

13. Perinatal cells and biomaterials for wound healing

14. Placental Stem Cells

15. Therapeutic Effect of Extracellular Vesicles Derived from Adult/Perinatal Human Mesenchymal Stem Cells

Section III. Umbilical Cord-Derived Cells

16. Ex-vivo Expansion of Cord Blood Stem Cells

17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells

18. Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children

19. Phenotypic and Functional Characterization Perinatal Stem Cells Isolated from Umbilical Cord Tissue

20. Mesenchymal stromal cells from Wharton’s jelly (WJ-MSCs): coupling their hidden differentiative program with their frank immunomodulatory phenotype

21. Regeneration of ischemic cardiovascular damage using Jelly Wharton as an unlimited source of therapeutic stem cells

22. Phenotype with Focused Paracrine Fractions: Effecting Future Phenotype with Focused Paracrine Fractions

Section IV. Clinical and Industry Perspective

23. Clinical Translation of Perinatal Stem Cell Therapy

24. Current Clinical Trials utilizing Perinatal Stem Cells – A Review

25. Review Of Processing Technology and Techniques for Perinatal Stem Cells Banking And Clinical Applications

26. Clinical Development And Commercialization Of Placenta-Derived Cell Therapy

27. How the patent landscape has changed

28. The Need for Better Assays to Predict the Effectiveness of Tissue Stem Cell Treatments