Structural and Mechanistic Enzymology

Structural and Mechanistic Enzymology, Volume 109, the latest release in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Chapters in this new volume include Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies, Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design, Computational Biochemistry─Enzyme Mechanisms Explored, and A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase. This series presents new information on protocols and analysis of proteins, with each volume guest edited by leading experts in a broad range of protein-related topics.

This volume presents state-of-the-art contributions, providing insights into the relationship between enzyme structure, catalysis, and function.

Provides cutting-edge developments in protein chemistry and structural biologyFeatures new information about protocols and analysis of proteinsContains chapters written by authorities in their respective fieldsTargeted to a wide audience of researchers, specialists and students

1. Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies Tatyana G. Karabencheva-Christova, Christo Z. Christov and Gregg B. Fields 2. Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design Andrew P. Montgomery, Kela Xiao, Xingyong Wang, Danielle Skropeta and Haibo Yu 3. Computational Biochemistry─Enzyme Mechanisms Explored Martin Culka, Florian J. Gisdon and G. Matthias Ullmann 4. A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase Stephen L. Bearne and Martin St. Maurice 5. Striking Diversity in Holoenzyme Architecture and Extensive Conformational  Variability in Biotin-Dependent Carboxylases Liang Tong 6. Enzymology of Microbial Dimethylsulfoniopropionate Catabolism Mishtu Dey 7. Sortase Transpeptidases: Structural Biology and Catalytic Mechanism Alex W. Jacobitz, Michele D. Kattke, Jeff Wereszczynski and Robert T. Clubb 8. Biology, Mechanism, and Structure of Enzymes in the a-D-Phosphohexomutase Superfamily Kyle M. Stiers, Andrew G. Muenks and Lesa J. Beamer 9.Mechanistic Insights Into Catalytic RNA–Protein Complexes Involved in Translation of the Genetic Code Satya B. Routh and Rajan Sankaranarayanan