Oncogenomics: From Basic Research to Precision Medicine

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detail novel molecular classifications of tumors, and identify diagnostic and prognostic biomarkers for various types of cancers, including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice.

Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignanciesEmploys current knowledge in oncogenomics towards developing therapeutic interventions for various cancer typesFeatures a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

PART I: MOLECULAR MEDICINE: A NOVEL APPROACH TO CANCER INVESTIGATION 1. FROM THE DOUBLE HELIX TO ONCOGENOMICS AND PRECISION CANCER MEDICINE: AN EVOLVING STORY Franco Dammacco and Franco Silvestris 2. INTRATUMOR HETEROGENEITY: BIOLOGICAL AND CLINICAL IMPLICATIONS Rekha Gyanchandani, Nolan Priedigkeit, Ahmed Basudan and Adrian V. Lee 3. THE ROLE OF PROTEOMICS IN CANCER RESEARCH Carolina Panis, Stephany Correˆa, Renata Binato and Eliana Abdelhay 4. NEXT-GENERATION SEQUENCING IN CLINICAL PRACTICE Umberto Malapelle, Pasquale Pisapia, Francesco Passiglia, Amélie Dendooven, Patrick Pauwels, Roberto Salgado and Christian Rolfo 5. CANCER EPIGENETICS: ABERRANT DNA METHYLATION IN CANCER DIAGNOSIS AND TREATMENT Hideyuki Takeshima, Harumi Yamada and Toshikazu Ushijima 6. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Farhadul Islam, Vinod Gopalan and Alfred King-Yin Lam 7. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Ahmad R. Safa 8. TARGETING THE HEDGEHOG AND NOTCH SIGNALING PATHWAYS IN CANCER STEM CELLS Ankita Borah and D. Sakthi Kumar 9. CANCER STEM CELLS IN MULTIPLE MYELOMA AND THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES Franco Dammacco, Patrizia Leone, Franco Silvestris, Vito Racanelli and Angelo Vacca

PART II: ONCOGENOMICS: CIRCULATING BIOMARKERS IN CLINICAL ONCOLOGY 10. BONE METASTASES FROM SOLID TUMORS: IN SEARCH OF PREDICTIVE BIOMARKERS FOR CLINICAL TRANSLATION Franco Silvestris, Stella D’Oronzo, Domenica Lovero, Raffaele Palmirotta and Franco Dammacco 11. LIQUID BIOPSY AND GENOMIC ASSESSMENT FOR LUNG CANCER: THE ROLE IN CLINICAL PRACTICE? Véronique Hofman, Simon Heeke, Maryline Allègra, Marius Ilié and Paul Hofman 12. PROGNOSTIC AND PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS Francesco Schettini, Mario Giuliano and Massimo Cristofanilli 13. CIRCULATING MIRNAS AS TUMOR BIOMARKERS Vikas Ghai, Inyoul Lee and Kai Wang 14. CIRCULATING DNA IN CANCER DIAGNOSIS AND PROGNOSIS Eveline E. Vietsch and Anton Wellstein 15. SEQUENCING A SINGLE CIRCULATING TUMOR CELL FOR GENOMIC ASSESSMENT Lei Xu, Nuria Coll Bastus and Yong-Jie Lu 16. SINGLE NUCLEOTIDE POLYMORPHISMS IN CANCER RESEARCH AND TREATMENT Massimo Di Maio

PART III: GASTROINTESTINAL TUMORS: MOLECULAR DIAGNOSIS AND TREATMENT 17. GASTRIC CANCERS: A MOLECULAR ROADMAP FOR PATIENT STRATIFICATION AND TARGETED THERAPIES Maxime Chénard-Poirier and Elizabeth C. Smyth 18. RESISTANCE TO EGFR TARGETING TREATMENTS IN COLORECTAL CANCER Michela Pucci and Mattia Lauriola 19. CIRCULATING DNA AND PROTEIN BIOMARKERS FOR THE TREATMENT OF TYROSINE KINASE INHIBITORS IN METASTATIC COLORECTAL CANCER Kjetil Søreide 20. RATIONALE FOR IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANCIES Vasiliki Michalarea and Elizabeth Smyth 21. PROTEOMICS PROFILING OF PANCREATIC CANCER: ROLES IN BIOMARKER DISCOVERY Hong Peng, Ru Chen and Sheng Pan 22. EMERGING TECHNOLOGIES FOR THE DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER Magdalena Swierczewska, Serguei Kozlov and Pavan P. Adiseshaiah 23. PERSONALIZED MEDICINE IN GASTROINTESTINAL STROMAL TUMORS Margherita Nannini and Guido Biasco 24. CIRCULATING MICRORNAS AS TUMOR BIOMARKERS IN HEPATOCELLULAR CARCINOMA Albrecht Piiper and Oliverwaidmann

PART IV: PERSPECTIVES IN BREAST CANCER GENOMICS 25. GENE PROFILES IN BREAST CANCER: TRANSLATION TO CLINICAL MEDICINE Serena Di Cosimo, Maria Grazia Daidone and Vera Cappelletti 26. NOVEL BIOMARKERS PREDICTING THE DEVELOPMENT OF BONE METASTASIS IN EARLY BREAST CANCER Michele Iuliani, Paolo Manca, Giulia Ribelli, Sonia Simonetti, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini 27. HER2-POSITIVE EARLY BREAST CANCER: AFFORDABLE RISKS, AFFORDABLE THERAPIES, AND NEW DEVELOPMENTS Pierfranco Conte, Mariavittoria Dieci, Graziavernaci and Valentina Guarneri 28. ROLE OF CIRCULATING TUMOR CELLS IN BREAST CANCER PATIENTS Rita Lampignano, A.M. Sofie Berghuis, Tanja Fehm and Hans Neubauer 29. OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER: MTOR INHIBITORS AND NEW DRUGS Paola Ferrari and Andrea Nicolini 30. EXPLORE GENOMIC PROFILES FOR TRIPLE-NEGATIVE BREAST CANCER TO DISCOVER DRUG TARGETS Xiaosheng Wang 46. BRAF-MUTANT MELANOMA: TREATMENT APPROACHES AND RESISTANCE MECHANISMS Svenja Meierjohann and Bastian Schilling