Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.

Synthesizes actual knowledge on mitochondrial functionProvides an integrated vision of each tissue in the etiology of obesity and type 2 diabetesIdentifies the interactive networks that involve alteration in mitochondrial mass and function in disease progressionHighlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

1. Mitochondrial function and structure 2. Mitochondria as signaling platforms 3. Hormonal and humoral regulation of mitochondrial function 4. Nutritional regulation of mitochondrial function 5. Mitochondrial DNA genetic and heteroplasmy 6. Role of mitochondria in the skeletal muscle metabolism in obesity and type 2 diabetes 7. Role of mitochondria in the metabolism of adipose tissues in obesity and type 2 diabetes 8. Role of mitochondria in the liver metabolism in obesity and type 2 diabetes 9. Role of mitochondria in the pancreatic beta-cells metabolism in obesity and type 2 diabetes 10. Role of mitochondria in the cardiovascular comorbidities associated to obesity and type 2 diabetes 11. Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes 12. Role of mitochondria in the regulation of the central nervous system in obesity and type 2 diabetes 13. Impact of fetal programming on mitochondrial function and susceptibility to obesity and type 2 diabetes 14. Role of mitochondria in cancers associated to obesity and type 2 diabetes 15. Role of mitochondria in neurodegeneration in obesity and type 2 diabetes 16. Mitochondria as a target of drug toxicity and pollution: potential involvement in the development of obesity and type 2 diabetes 17. Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes 18. State of knowledge and recent advances in prevention and treatment of mitochondrial dysfunction in obesity and type 2 diabetes 19. Concluding chapter on "Mitochondria in obesity and type 2 diabetes"