Functional Neural Transplantation IV: Translation to Clinical Application, Part A

Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation.

As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

1. Mechanisms and Use of Neural Transplants for Brain Repair    Stephen B. Dunnett and Anders Björklund 2. Reprogramming of Somatic Cells: iPS and iN Cells    Vania Broccoli 3. Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons    Olof Torper and Magdalena Götz 4. Ex Vivo Gene Therapy for the Treatment of Neurological Disorders    Genevieve Gowing , Soshana Svendsen  and Clive N. Svendsen 5. Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation: Scale Up, Fingerprinting and Genomic Stability of Stem Cell Lines    Ammar Natalwala and Tilo Kunath 6. Regulatory Considerations for Pluripotent Stem Cell Therapies    Melissa K. Carpenter 7. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: A European Approach (STEM-PD)    Agnete Kirkeby, Malin Parmar and Roger A. Barker 8. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: The NYSTEM Trial    Lorenz Studer 9. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: The Kyoto Trial    Jun Takahashi 10. From Open to Large-Scale Randomised Cell Transplantation Trials in Huntington´s Disease: Lessons from the Multicentric Intracerebral Grafting in Huntington’s Disease Trial (MIG-HD) and Previous Pilot Studies    Anne-Catherine Bachoud-Lévi 11. Pluripotent Stem Cell-derived neurons for Transplantation in Huntington´S Disease    Meng Li and Anne E. Rosser 12. Advanced Imaging of Transplant Survival, Fate, Differentiation, and Integration    Nadja Van Camp, Elsa Diguet and Philippe Hantraye 13. Rehabilitation Training in Neural Restitution    Susanne Clinch, Monica Busse, Mate D. Döbrössy and Stephen B. Dunnett