Chemical Glycobiology: Synthesis, Manipulation and Applications of Glycans

Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases, Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates.

Readers will find the latest information on this developing area of research, as reported by leaders in the field.

1. Discovery of New Glycosidases from Metagenomic Libraries Stephen George Withers, Zach Armstrong and Peter Rahfeld 2. Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme David Kwan 3. A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases Matt DeLisa 4. Directed evolution of glycopeptides using mRNA display Isaac Krauss 5. Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars Barbara Imperiali and Cristina Zamora 6. Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates Michel Gilbert, Ian Schoenhofen and Martin Young 7. Syntheses of fluorescent gangliosides for the studies of raft domains Makoto Kiso 8. Profiling of Sugar Nucleotides Rob Field 9. Chemoenzymatic glycan remodeling of natural and recombinant glycoproteins Lai-Xi Wang 10. Glycoengineered Outer Membrane Vesicles as a platform for vaccine development Mario Feldman 11. Identification and Design of Synthetic B Cell Epitopes for Carbohydrate-based Vaccines Peter Seeberger and Felix Broecker 12. Strategies in the Design and Use of Synthetic ‘Internal Glycan’ Vaccines Ben Davis 13. Evaluation of Virus Like Particle Based Tumor-Associated Carbohydrate Immunogen in a Mouse Tumor Model Xuefei Huang, Xuanjun Wu and Suttipun Sungsuwan