Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties.

Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compoundsIncludes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalizationHighlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

1. Future of Drug Discovery: Importance of modified nucleosides, Nucleotides and Oligonucleotides 2. Stille Cross-Coupling Reaction: Early years to the current state-of the art 3. Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification 4. Sonogashira Cross-Coupling: Alkyne-modified Nucleosides and their Applications 5. Application of Heck Alkenylation Reaction in Modified Nucleoside Synthesis 6. Nucleosides Modification Using Buchwald-Hartwig Amination Reactions 7. Transition-Metal Catalyzed Modification of Nucleosides 8. C-H Bond Functionalisation Strategies for Modification of Nucleosides 9. Synthesis and applications of water soluble Pd-catalyst systems for introduction of C-C bond in nucleosides 10. Advances in application of Pd-mediated transformations in nucleotides and oligonucleotides