Epigenetics of Aging and Longevity: Translational Epigenetics vol 4

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail.

This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related diseaseProvides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectoryApplies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Section I: Epigenetic Mechanisms in Aging 1. Aging epigenetics: changes and challenges 2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns 3. S-adenosylmethionine Metabolism and Aging 4. The Epigenetic Clock and Ageing 5. The Epigenetic Regulation of Telomere Maintenance in Aging 6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype? 7. Epigenetic Biomarkers for Biological Age 8. The Role of Non-Coding RNAs in Genome Stability and Aging 9. Intra-tissue DNA methylation heterogeneity in aging

Section II. Early-life Epigenetic Programming of Aging Trajectories 10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life 11. Early Nutrition, Epigenetics and Human Health 12. Biological Embedding of Psychosocial Stress over the Life Course 13. Epigenetics of longevity in social insects

Section III. Epigenetics of Aging-Associated Diseases 14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging 15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms 16. Epigenetics of brain/cognitive aging 17. The role of epigenetic modifications in cardiometabolic diseases 18. Epigenetic mechanisms in osteoporosis 19. Epigenetics of Skeletal Muscle Aging

Section IV. Epigenome-targeted Therapies in Gerocscience 20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective 21. Epigenetic Drugs for Cancer and Precision Medicine 22. Epigenetic Drug Discovery for Alzheimer’s Disease

Section V. Conclusions and Perspectives 23. Epigenetics of aging and longevity: challenges and future directions