Cancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.

This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapiesFeatures contributions by leading experts in the field

1. Introduction

SECTION I: NON-CODING RNAs: FINE-TUNING CANCER 2. miRNA and Cancer: A Deadly Liaison? 3. Alteration of MicroRNA Biogenesis Pathways in Cancers 4. MicroRNAs In Exosomes in Cancer 5. Circulating miRNAs Incresaing the Risk of Cancer 6.  Long Noncoding RNAs as Cancer Biomarkers 7. The Balancing Act: Understanding MicroRNA and Competing Endogenous RNA Regulation in Cancer 8. PIWI-Interacting RNAs (piRNAs) and Cancer 9. Transfer RNA in Cancer 10. Dynamic Regulation of tRNA Modifications in Cancer 11. Circular RNA: A Novel Noncoding RNA in Cancer 12. Antisense RNA and Cancer 13. Implication of Other Noncoding RNAs in Cancer

SECTION 2: GENETIC DYSREGULATION OF NON-CODING RNA IN CANCER 14. Noncoding RNA Alterations in Cancer Molecular Pathways 15. Genetic Alteration of MicroRNA Affecting Cancer Pathways 16. Genetic Variations of Long Noncoding RNAs in Cancer

SECTION 3: EPIGENETIC EFFECT ON CANCER THROUGH NON-CODING RNAs 17. Cross Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer 18. Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification Complexes in Cancer 19. Heterochromatin Modulation and PcG Control of Gene Expression Medicated by Noncoding RNA in Cancer 20. Epigenetic Control of MicroRNA Expression and Cancer 21. Implications of Long Noncoding RNAs in Cancer Epigenetics

SECTION 4: THERAPEUTIC IMPLICATIONS OF NON-CODING RNA IN CANCER 22. Long Noncoding RNAs: Insight Into Their Roles in Normal and Cancer Stem Cells 23. Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of Noncoding RNAs in Cancer 24. Noncoding RNAs: Novel Targets in Anticancer Drug Development

SECTION 5: BIOINFORMATICS' DETECTION OF NON-CODING RNA IN CANCER 25. Cancer Noncoding RNA Discovery Through High-Throughput Sequencing 26. Noncoding RNAs as a Cauce of Cancer: Evidence From Genome-Wide Association Studies and Reverse Genetics 27. A Comparative Evaluation of Emerging Databases and Tools for Cancer Noncoding RNAs 28. Future Directions and Challenges Involved in Cancer Noncoding RNomics