Skin Tissue Models

Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies.

The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro modelsAddresses legal requirements and ethical concerns in drugs and cosmetics in vitro testingEdited and authored by internationally renowned group of researchers, presenting the broadest coverage possible

Section 1 – Therapeutic Molecules and Cosmetics Testing 1. Cosmetic industry requirements regarding skin models for cosmetic testing   Christian Pellevoisin, Charbel Bouez, José Cotovio 2. Overall perspective on the clinical importance of skin models   Yusef Yousuf, Saeid Amini-Nik, Marc G. Jeschke,

Section 2 - Skin Diseases: clinical demands and diseased-skin in vitro models 3. In vitro models of Melanoma   Dagmar Kulms, Friedegund Meier 4. Organotypic and humanized animal models of genodermatoses   Esteban Chacón-Solan, Sara Guerrero-Aspizua, Lucía Martínez-Santamaría, Marcela Del Rio, Fernando Larcher 5. In vitro models of Psoriasis   Bryan Roy, Mélissa Simard, Isabelle Lorthois, Audrey Bélanger, Maxim Maheux, Alexandra Duque-Fernandez, Geneviève Rioux, Philippe Simard, Marianne Deslauriers, Louis-Charles Masson, Alexandre Morin and Roxane Pouliot 6. In vitro models of Vitiligo Muriel Cario-André, Katia Boniface, François-Xavier Bernard, Alain Taieb, Maria Lucia Dell’Anna, Julien Seneschal 7. In vitro models of squamous cell carcinoma   Elizabeth Pavez Loriè, Hans-Jürgen Stark, Manuel Berning, Petra Boukamp

Section 3 – Skin Substitutes: Clinical demands and skin tissue equivalents 8. Strategies to promote the vascularization of skin substitutes after transplantation   Jennifer Bourland, Julie Fradette 9. On the path to scarring-free skin regeneration approaches   Mohammed Ashrafi, Adam Hague, Mohamed Baguneid, Teresa Alonso-Rasgado, Ardeshir Bayat 10. Pre-clinical Models for Wound Healing Studies   Irena Pastar, Liang Liang, Andrew P Sawaya, Tongyu Cao Wikramanayake, George D Glinos, Stephan Drakulich, Vivien Chen, Olivera Stojadinovic, Stephen C Davis, and Marjana Tomic-Canic 11. The importance of targeting inflammation in skin regeneration   Megan Schrementi, Lin Chen, Luisa Ann DiPietro

Section 4 – In Vitro Models as study platforms of skin Biology 12. In Vitro Models to study hair follicles generation   Ana Korosec, Beate Maria Lichtenberger 13. In Vitro Models to study cutaneous innervation mechanisms   Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Jérémy Chéret, Raphaël Leschiera, Matthieu Talagas, Raphaële Le Garrec, Virginie Buhé, Killian L’herondelle, Olivier Gouin, Mehdi Sakka, Nicholas Boulais, Ulysse Pereira, Jean-Luc Carré, Laurent Misery 14. Skin in vitro models to study dermal white adipose tissue role in skin healing   Manuela E. L. Lago, Mariana T. Cerqueira, Rogério P. Pirraco, Rui L. Reis, Alexandra P. Marques 15. Immunocompetent in vitro skin models   Victoria Hutter, Stewart B Kirton, David YS Chau

Section 5 - Emerging technologies for the development of 3D skin models 16. Additive manufacturing in the development of 3D skin models   Kelsey Retting, Deborah G. Nguyen 17. Induced Pluripotent Stem Cells Potential to generate skin tissue models   Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini, Jonathan A. Garlick 18. Requirements of skin tissue models for high throughput screening   Stephanie H. Mathes, Christian N. Parker