Regenerative Nephrology

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchersExperts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION * Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach Yuko Wakamatsu and Hisashi Hashimoto * Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia Marc R. Hammerman * Use of Genetic Mouse Models to study Kidney Regeneration Akio Kobayashi and Jeremy S. Duffield MEDIATORS OF REGENERATION * Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease Charles N. Serhan and Catherine Godson * Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser * Mast cells in kidney regeneration Eric Daugas, Walid Beghdadi and Ulrich Blank * Role of macrophages in renal injury, repair and regeneration Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris * T-cells contribution to regenerative processes Hamid Rabb STEM CELLS IN REGENERATIVE PROCESSES * MSC and reparative processes Benjamin D. Humphreys and John V. Bonventre * Stem cells in regenerative processes: Endothelial progenitor cells and the kidney Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink * The potential of the side population in regenerative nephrology Melissa H. Little and G. A. Challen * Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak * Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells Kenji Osafune and Shinya Yamanaka * Methods of Isolation and Culture of Adult Stem cells Lindolfo da Silva Meirelles and Nance Beyer Nardi STEM CELLS - FROM THE NICHE TO REPAIR * Stem cell niche in the kidney Laura Lasagni, Elena Lazzeri and Paola Romagnani * Creation of artificial niches Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky * Imaging of transplanted and native stem cells Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman CAUSES OF REGENERATIVE FAILURE * Stem cell injury and premature senescence Michael S. Goligorsky * Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering * BONE MARROW-MESENCHYMAL STEM CELLS IN ORGAN REPAIR AND STRATEGIES TO OPTIMIZE THEIR EFFICACY Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY * Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data Florian E. Togel and Christof Westenfelder * Clinical trials in Renal Regenerative Medicine Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar * Potential risks of stem cell therapies Uta Kunter and Jurgen Floege * Tissue engineering in urology Anthony Atala * Ethical issues in SC therapy Donald W. Landry * Stem Cell Banking Vicente Mirabet and Pilar Solves