Immunology: Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy

Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

Presents the most advanced information regarding the role of autophagy and immunityIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell deathEdited work with chapters authored by leaders from around the globe – the broadest, most expert coverage available

I. MOLECULAR MECHANISMS 1. Introduction to Immunology  2. Cytomegalovirus and Autophagy 3. The Role of Macroautophagy in T Cells 4. Increased Immunogenicity through Autophagy 5. Regulation of Humoral Immunity by CD1D-Restricted Natural Killer T Cells 6. Signaling by the Toll-like Receptors Induces Autophagy through Modification of Beclin-1: Molecular Mechanism 7. Molecular Mechanisms Underlying the Action of Ipilimumab against metastatic melanoma 8. To Help or To Harm: Dynamic Roles of CD4+ T Helper Cells in Solid Tumor Microenvironments 9. Development and Function of Nk Cells and its Importance in Cancer Immunotherapy

II. ROLE IN DISEASE AND TREATMENT  10. Varicella Zoster Vaccine Experience in HIV-Infected Children and Adolescents 11. Development of An Effective Alzheimer’s Vaccine 12. Obesity-induced Defects in Dendritic Cell and T Cell Functions: Implications for Immunotherapeutic Efficacy in Cancer 13. Redox-Dependent Circuits Regulating B Lymphocyte Physiology 14. Immunomodulatory Attributes of Aged Garlic Extract and Its Components 15. MUC 1 and Cancer Immunotherapy