Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases.

Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed.

Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs.

Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discoveryIncludes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseasesOffers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

1. Natural Products as a source of neuroprotective agents for Parkinson’s Disease 2. Discovery of neuroprotective antioxidants for the management of ischemic brain stroke 3. Discovery of biophenols for application in Alzheimer’s Disease 4. Identification and Development of Naturally Occurring Anti-Inflammatory Steroid Analogues for Neuroprotection 5. Neuroprotective plant alkaloids: structure activity and synthetic analogues 6. Coumarin-based molecules as suitable models for developing new neuroprotective agents through structural modification 7. Phytochemistry and Pharmacology of Lycium barbarum L. and Schisandra chinensis (Turcz.) Baill" or "Neuroprotective phytochemicals of Lycium barbarum L. and Schisandra chinensis (Turcz.) Baill" 8. Neuroactive Components of Culinary and Medicinal Mushrooms with Potential to Mitigate Age Related Neurodegenerative Diseases