Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity.

Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possibleProvides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safetyIncludes a section on risk communication of these complex concepts, essential for effective risk assessmentProvides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Preface
1. Introduction
2. Historical Development of Biomarkers
3. Computational Toxicology
4. Omic Biological Markers
5. Validation of Biological Markers for Epidemiological Studies
6. Technical Translational Analysis of Biological Marker Data
7. QA/QC of Biological Marker Data Sets
8. Translation of Biomarkers for Human Clinical and Epidemiological Studies
9. Risk Communication of Molecular Biological Marker Information
10. Future Research Directions
Appendices