Handbook of Synthetic Organic Chemistry

Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions.

The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product.

From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process.

Contains practical information for every part of the process that are coupled with engaging, real-world examplesPresents useful guidance for conducting literature searches, handling and preparing reagents, working up the reaction, and identifying the productPresents valuable coverage of conventional and microwave temperature control, paper and electronic research notebooks, eluent selection, Schlenk lines, purification methods and determination, chiral chromatography, chemical safety, and more

1. Safety 2. Searching the Literature 3. Reagents 4. Gases 5. Reactions on a Small Scale—1–25mmol 6. Temperature Control 7. Solvents 8. The Research Notebook 9. Conducting the Reaction Itself 10. Following the Reaction 11. Working Up Reactions 12. Evaporation 13. Vacuum Systems 14. Purification of Products 15. Methods for Structure Elucidation 16. Cleaning Up After the Reaction 17. Specific Example 18. Strategies for Reaction Optimization