Type 2 Diabetes and Dementia

Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology.

Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinologyIncludes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications

1. Introduction
2. Epidemiology of type 2 diabetes and dementia
3. Magnitude and trajectories of Type 2 diabetes mellitus (DM)-associated cognitive dysfunction
4. Brain Imaging in Diabetes
5. Cerebrospinal Fluid and Blood-Based Biomarkers in Alzheimer’s Disease and Type 2 Diabetes Spectrum Disorders
6. Neuropathologic insights into diabetes
7. Diet, obesity, exercise, metabolism and brain
8. The role of insulin resistance and signalling in dementia
9. Advanced Glycation, Diabetes and Dementia
10. Neuroinflammation, Type 2 Diabetes and Dementia
11. The blood-brain barrier in diabetes mellitus
12. Pharmacological and non-pharmacological interventions for cognitive impairment and dementia related to type 2 diabetes and metabolic disturbances in aging