Clinical Molecular Medicine: Principles and Practice

Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances.

Illustrates the fundamental principles and therapeutic applications of molecular and cellular biologyOffers a clinically focused account of molecular heterogeneityIncludes comprehensive coverage of many different disorders, including growth and development, cardiovascular, metabolic, skin, blood, digestive, inflammatory, neuropsychiatric disorders, and many more

Part I. FUNDAMENTALS OF MOLECULAR MEDICINE 1. The human genome and molecular medicine 2. Cellular structure and molecular cell biology 3. Molecular basis of clinical metabolomics 4. Clinical applications of next-generation sequencing

Part II. MOLECULAR MEDICINE IN CLINICAL PRACTICE 5. Molecular basis of obesity disorders 6. Molecular dysmorphology 7. Disorders of sex development 8. Molecular systems in cardiovascular developmental disorders 9. Channelopathies in clinical medicine—cardiac arrhythmias 10. Chronic heart failure 11. Molecular pathophysiology of systemic hypertension 12. Molecular basis of stroke 13. Clinical molecular endocrinology 14. Genetic disorders of lipoprotein metabolism 15. Molecular medicine of diabetes mellitus 16. Molecular genetic management of epilepsy 17. The human leukocyte antigen system in human disease and transplantation medicine 18. Disorders of abnormal hemoglobin 19. Coagulation and bleeding disorders 20. Molecular and genomic basis of bronchial asthma 21. Molecular systems in inflammatory bowel disease 22. Molecular biology of acute and chronic inflammation 23. Molecular basis of susceptibility and protection from microbial infections 24. Molecular mechanisms in cancer susceptibility—lessons from inherited cancers 25. Clinical molecular nephrology—acute kidney injury and chronic kidney disease 26. Molecular basis of chronic neurodegeneration 27. Molecular basis of movement disorders 28. Molecular pathology in neuropsychiatric disorders 29. Targeted molecular therapy: the cancer paradigm 30. Gene, genome, and molecular therapeutics 31. Personalizing medicine with pharmacogenetics and pharmacogenomics 32. Integrated genomic and molecular medicine