Nitric Oxide Donors: Novel Biomedical Applications and Perspectives

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications.

This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications.

The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions.

Provides background information about biology and chemistry of nitric oxideDiscusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applicationsCovers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunityDiscusses the future of nitric oxide donors and their FDA approval

1. Nitric Oxide Derivative Ruthenium Compounds as NO-Based Chemotherapeutic and Phototherapeutic Agents 2. Nitric Oxide Donors for Treating Neglected Diseases 3. Nitric Oxide-Donating Devices for Topical Applications 4. Nitric Oxide Donors and Therapeutic Applications in Cancer 5. Nitric Oxide Donors and Penile Erectile Function 6. Nitric Oxide Donors in Nerve Regeneration 7. Nitric Oxide Donors as Antimicrobial Agents 8. Improving the Performance of Implantable Sensors with Nitric Oxide Release 9. Strategies to Deliver Nitric Oxide Donors to Control Biofilms of Clinical and Industrial Interest 10. Developing New Organic Nitrates for Treating Hypertension 11. Nitric Oxide Donors in Brain Inflammation 12. Synergistic Activities of Nitric Oxide and Various Drugs 13. Hydrogels for Topical Nitric Oxide Delivery