Mutagenicity: Assays and Applications

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation.

By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

Presents an up-to-date and in-depth review of the current state of mutagenesis researchDraws upon the combined experience and expertise of an international group of highly respected editors and chapter authorsProvides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

1. Mutagenesis and health problems
2. Molecular mechanisms of mutagenesis
3. Bacterial mutation assays
4. Gene mutation assays in cultured mammalian cells
5. Chromosomal aberration test
6. In vivo cytogenetic assay
7. Mutagenicity testing in environmental pollution control
8. Mutagens in food and water
9. Emerging methods for the identification of mutagens
10. Guidelines and registration of the new compounds or drug like molecules
11. Mutagenicity testing, regulatory guidelines and current needs