Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated.

Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level.

Edited and authored by world-leading chromatography expertsProvides comprehensive coverage of SFC in a single sourceExtensive referencing facilitates identification of key research developmentsMore than 200 figures and tables aid in the retention of key concepts

1. Milestones in Supercritical Fluid Chromatography: A Historical View of the Modernization and Development of Supercritical Fluid Chromatography 2. Theory of Supercritical Fluid Chromatography 3. Practical Approaches to Column Selection for Supercritical Fluid Chromatography 4. Column Characterization 5. Method Development in Supercritical Fluid Chromatography 6. Application of Multiple Column Supercritical Fluid Chromatography 7. Evolution of Instrumentation for Analytical Scale Supercritical Fluid Chromatography 8. Hyphenated Detectors: Mass Spectrometry 9. Theories for Preparative SFC 10. Practical Aspects and Applications of Preparative Supercritical Fluid Chromatography 11. Validation of Supercritical Fluid Chromatography Methods 12. Separation of Stereoisomers 13. Supercritical Fluid Chromatography of Petroleum Products 14. Separation of Lipids 15. Separation of Natural Products 16. Pharmaceutical Applications 17. Applications to Food Analysis 18. Physicochemical Property Measurements Using SFC Instrumentation