Fundamentals of Toxicology: Essential Concepts and Applications

Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding.

The first unit provides extensive coverage on the background of toxicology including commonly used definitions and historical perspective, while following units cover: basic concepts; regulatory requirements and good laboratory practices, including types of toxicology testing and evaluation; toxic agents and adverse effects on health; and analytical, forensic, and diagnostic toxicology. This is an essential book for advanced students in toxicology and across the biomedical sciences, life sciences, and environmental sciences who want to learn the concepts of toxicology, as well as early researchers needing to refresh outside of their specialty.

Explains the essential concepts of toxicology in a clear fashionProvides in-depth coverage of testing protocols, common drugs, chemicals, and laboratory-based diagnostic and analytical toxicologyExplores the history, foundations, and most recent concepts of toxicologyServes as an essential reference for advanced students in toxicology and across the biomedical, life, and environmental sciences who want to learn the concepts of toxicology

Unit I

Chapter 1. Introduction and historical background

Chapter 2. Definitions and scope of toxicology

Chapter 3. Classification of poisons/toxicants

Chapter 4. Factors affecting toxicity

Chapter 5. Natural laws concerning toxicology

Chapter 6. Hazard and risk assessment

Unit II

Chapter 7. Absorption, distribution, and excretion of toxicants

Chapter 8. Biotransformation

Chapter 9. Principles and basic concepts of toxicokinetics

Unit III

Chapter 10. Toxicological testing: Genesis

Chapter 11. Toxicological testing: In vitro models

Chapter 12. Toxicological testing: In vivo systems

Chapter 13. Genotoxicity

Chapter 14. Preclinical toxicological investigations of pharmaceutical products

Chapter 15. Preclinical safety evaluation of biotechnology-derived products

Chapter 16. Preclinical regulatory toxicology for biomaterials and medical devices

Unit IV

Chapter 17. Toxic effects of pesticides (agrochemicals)

Chapter 18. Toxic effects of metals

Chapter 19. Toxic effects of nonmetallics

Chapter 20. Neurotoxic agents

Chapter 21. Toxic effects of cardiac poisons

Chapter 22. Toxic effects of asphyxiants

Chapter 23. Toxic effects of caustics (corrosives)

Chapter 24. Drug toxicity, dependence, and abuse

Chapter 25. Toxic effects of domestic chemicals

Chapter 26. Toxic effects of poisonous plants

Chapter 27. Poisonous foods and food poisoning

Chapter 28. Poisons of animal origin

Chapter 29. Chemical food poisoning

Chapter 30. Health effects of radioactive materials

Unit V

Chapter 31. Basic concepts of forensic toxicology

Chapter 32. Applications in toxicology

Chapter 33. Clinical toxicology

Chapter 34. Treatment of poisoning