Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods

Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures.

The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host.

These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.

Includes such major areas of coverage as host-derived factors, innate immunity of arthropod presentations and the arthropod microbiome/symbiontsFeatures expertly curated topics, ensuring appropriate scope of coverage and aid integration of concepts and contentProvides the necessary scientific background for the development of the research and discussions that have laid the groundwork for future efforts, including the Keystone Symposium and relevant meetings at NIAID/NIH

1. The Site of the Bite: Addressing Knowledge Gaps in Vector Transmission of Diseases
2. Conservation and Convergence of Immune Signaling Pathways With Mitochondrial Regulation in Vector Arthropod Physiology
3. Wolbachia-Mediated Immunity Induction in Mosquito Vectors
4. Modulation of Mosquito Immune Defenses as a Control Strategy
5. Molecular Mechanisms Mediating Immune Priming in Anopheles gambiae Mosquitoes
6. The Mosquito Immune System and Its Interactions With the Microbiota: Implications for Disease Transmission
7. Using an Endosymbiont to Control Mosquito-Transmitted Disease
8. Effect of Host Blood–Derived Antibodies Targeting Critical Mosquito Neuronal Receptors and Other Proteins: Disruption of Vector Physiology and Potential for Disease Control
9. Role of the Microbiota During Development of the Arthropod Vector Immune System
10. Host–Microbe Interactions: A Case for Wolbachia Dialogue
11. The Gut Microbiota of Mosquitoes: Diversity and Function
12. Targeting Dengue Virus Replication in Mosquitoes
13. Paratransgenesis Applications: Fighting Malaria With Engineered Mosquito Symbiotic Bacteria
14. Insulin-Like Peptides Regulate Plasmodium falciparum Infection in Anopheles stephensi