Strategies for Palladium-Catalyzed Non-directed and Directed C bond H Bond Functionalization

Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization portrays the complete scope of these two aspects of C-H bond functionalization in a single volume for the first time. Featured topics include the influence of palladacyclic systems in C-H bond functionalization (need for newer catalytic systems for better efficiency), mechanistic aspect of the functionalization strategies leading to better systems, and applications of these methodologies to natural product synthesis and material synthesis.

Addresses the involvement of catalytic systems (palladacycles) for better functionalization of (hetero)arenes to emphasize the need for developing better, more selective systemsCovers the use of powerful mechanistic tools for understanding and assisting the development of better functionalization strategiesDiscusses the finer aspects of C-H bond functionalization, such as control of regioselectivity with or without directing groupsIncludes a chapter detailing the synthesis of naturally occurring molecules or functional molecules via both pathways for assessing the applicability of the functionalization strategies

1. Introductory chapter on C-H bond functionalization
2. Oxidative Coupling of Aromatic C-H Bonds
3. Directed C-H bond functionalization of heteroarenes
4. Non-directed C-H bond functionalizations of heteroarenes
5. Palladium-Catalyzed Arylation (or Functionalization in general) of Unactivated spz C–H bond
6. C-H bond functionalization at the benzene core of indoles and indolines (excluding C-2 and C-3)
7. Palladium Catalyzed Carbonylative and Carboxylative C-H Functionalization Reactions: Importance and Role of Regioselectivity
8. Flow Chemistry Perspective for C-H Bond Functionalizations
9. Meta selectivity in Directed C-H bond functionalizations
10. Aliphatic distal C-H activation
11. Palladacycles for Directed and Non-Directed C-H bond Functionalization of Heteroarenes
12. Mechanistic Aspect of Directed and Non-Directed C-H Bond Functionalizations
13. Total Synthesis of Natural Products by C-H Activation