Autophagy and Cardiometabolic Diseases: From Molecular Mechanisms to Translational Medicine

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases.

By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseasesProvides knowledge from internationally recognized contributors in the fieldIncorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseasesContains access to a companion website with additional illustrations

Section I. Cell biology of cardiometabolic syndrome and autophagy 1. Overview of cardiometabolic syndrome 2. Overview of autophagy and its molecular regulation 3. Interplay among oxidative stress, redox signaling, ER-stress, autophagy and protein ubiquitination 4. Selective autophagy for specific organelles 5. Experimental models of autophagy and measurement of autophagy 6. Role of autophagy in cardiac physiology and pathophysiology

Section II. Autophagy and pathogenesis of cardiometabolic disease 7. Autophagy and diabetes mellitus 8. Autophagy and hypertension 9. Myocardial Insulin Signaling and Autophagy 10. Autophagy and obesity 11. Autophagy and dyslipidemia 12. Autophagy and stroke 13. Polycystic Ovary Syndrome and Cardiometabolic Disease 14. Autophagy and thrombosis, vascular inflammation 15. Autophagy and Proteostasis in Cardiac Aging 16. Autophagy and central nervous system

Section III. Autophagy and complications of cardiometabolic disease 17. Autophagy and chronic liver disease 18. Autophagy in acute and chronic kidney disease 19. Autophagy and fetal programming 20. Autophagy, oxidative stress and redox regulation

Section IV. Translational approach of autophagy 21. Therapeutic drug discovery targeting autophagy I 22. Autophagy: A new therapeutic target 23. Autophagy regulates control of intracellular energy stores 24. Autophagy and epigenetics 25. Autophagy, exercise and life style modification