In Vitro Toxicology

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing.

Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.

1. Development of in vitro toxicology: A historic story
2. Principles for in vitro toxicology
3. Models and methods for in vitro toxicity
4. Methods for in vitro genotoxicity
5. Considerations of metabolism in in vitro toxicology
6. In vitro approaches for predictive biokinetics
7. Application of Omics Technologies to In Vitro Toxicology
8. Extrapolation of in vitro results to predict human toxicity
9. Nanotoxicity: an in vitro prediction
10. Scientific and regulatory considerations in the development of in vitro techniques for toxicology
11. Safety issues in the use tissues/in vitro methods for toxicity assessment
12. Future directions in in vitro toxicology