Congenital and Acquired Bone Marrow Failure

Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients.

Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.

Provides an overview of all congenital and acquired bone marrow failure syndromesFocuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromesFeatures the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services

1. Epidemiology of Acquired Bone Marrow Failure  2. Acquired Aplastic Anemia 3. Diagnosis of Acquired Aplastic Anemia 4. Acquired Overlap Bone Marrow Failure Disorders 5. Supportive Care in Aplastic Anemia 6. Immunosuppressive Treatment for Aplastic Anemia 7. Identical Sibling Donor Transplantation 8. Unrelated Donor Transplantation 9. Cord Blood Transplantation 10. Haploidentical Transplantation 11. Management of Acquired Aplastic Anemia in Children 12. Treatment of Elderly Patients with Aplastic Anemia 13. Emerging New Therapies for Acquired Bone Marrow Failure Disorders 14. Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria 15. Telomere Biology and Disease 16. Fanconi Anemia 17. Ribosomopathies and the quality control of ribosome assembly 18. Dyskeratosis Congenita 19. Amegakaryocytic Thrombocytopenia 20. Severe Congenital Neutropenias and Other Rare Inherited Disorders with Marrow Failure Disorders 21. Aplastic Anemia and Myelodyspastic Syndrome in Pediatic Age