Basement Membranes

Basement Membranes focuses on specialized extracellular matrices that provide the scaffolds used and required by cells to organize themselves into tissues and organs. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane field.

Written by leading experts in the basement membrane fieldContains original material, both textual and illustrative, that should become a very relevant reference materialPresents material in a very comprehensive mannerIdeal for both researchers in the field and general readers who will find relevant and up-to-date information

1. Integrating Activities of Laminins that Drive Basement Membrane Assembly and Function
   Peter D. Yurchenco
2. Laminin-a2 Chain-Deficient Congenital Muscular Dystrophy: Pathophysiology and Development of Treatment
   Madeleine Durbeej
3. Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms
   Mao Mao, Marcel V. Alavi, Cassandre Labelle-Dumais and Douglas B. Gould
4. Epidermal Basement Membrane in Health and Disease
   Cristina Has and Alexander Nyström
5. Applying Proteomics to Investigate Extracellular Matrix in Health and Disease
   Michael Randles and Rachel Lennon
6. Molecular Basis of Laminin–Integrin Interactions
   Masashi Yamada and Kiyotoshi Sekiguchi
7. Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View
   Corina M. Borza, Xiwu Chen, Roy Zent and Ambra Pozzi
8. The Basement Membrane Proteoglycans Perlecan and Agrin:  Something Old… Something New
   Kevin J. McCarthy
9. Building From the Ground Up: Basement Membranes in Drosophila Development
   Adam J. Isabella and Sally Horne-Badovinac
10. Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues
    Matthew R. Clay and David R. Sherwood