Recent Advances in Medicinal Chemistry, Volume 1

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

Edited and written by leading experts in medicinal chemistry researchReviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehiclesCovers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

1. New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs
2. Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium
3. Characterization of Inorganic Nanomaterials as Therapeutic Vehicles
4. Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women
5. Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics
6. Tannins and their Influence on Health
7. Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
8. Carotenoids that are Involved in Prostate Cancer Risk
9. Preclinical Studies of Saponins for Tumor Therapy
10. Pharmacological Neuroprotection for Acute Spinal Cord Injury
11. HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples
12. Gene Expression Profiles in Breast Cancer to Identify Estrogen Receptor Target Genes
13. Trans-Plasma Membrane Electron Transport in Human Blood Platelets: An Update
14. Role of Intermediate States in Protein Folding and Misfolding