Translational Advances in Gynecologic Cancers

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.

Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.

Provides a comprehensive description of all evolving translational gynecologic cancer research for cliniciansIdentifies knowledge gaps to inform the next research directionTies together clinical research and patient needs to help both the researcher and clinicianAddresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

Part I: Ovarian Cancer 1. Origins of Epithelial Ovarian Cancer 2. Ovarian Cancer Genomics 3. Epigenetics 4. Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma 5. Angiogenesis 6. Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics 7. Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy 8. Ovarian Cancer: New Targets and Future Directions 9. Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy 10. Updates on Rare Epithelial Ovarian Carcinoma

Part II: Endometrial Cancer 11. Endometrial Cancer Genomics 12. Sentinel Lymph Node Mapping Procedures in Endometrial Cancer 13. The Role of Radiation in Uterine Cancer

Part III: Cervical Cancer 14. Novel Therapies for Advanced Cervical Cancer

Part IV: Vulvar Cancer 15. New Therapies in Vulvar Cancer

Part V: Fertility and Cancer 16. Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery