Hyperpolarized and Inert Gas MRI: From Technology to Application in Research and Medicine

Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990’s, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.

HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer’s disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource.

Presents the most comprehensive, relevant, and accurate information on HP gas MRICo-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplinesServes as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRICovers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted

1. MRI Acquisition Techniques 2. The Physics of Hyperpolarized Gas MRI 3. Dynamic Imaging of Lung Ventilation and Gas Flow With Hyperpolarized Gas MRI 4. Persistence of Ventilation Defects in Asthmatics 5. Hyperpolarized ³He Gas MRI Studies of Pulmonary Disease 6. Pediatric Imaging and Cystic Fibrosis 7. Hyperpolarized Gas MRI of Radiation-Induced Lung Injury 8. Development and Application of Mouse Imaging Using Hyperpolarized Xenon 9. Quantitative Ventilation Imaging Using Hyperpolarized Gas and Multibreath Imaging Sequences 10. PAO₂ Mapping Using HP Gas MRI 11. Hyperpolarized Xenon-129 Dissolved-Phase Magnetic Resonance Imaging 12. Lung Morphometry With HP Gas Diffusion MRI: From Theoretical Models to Experimental Measurements 13. CT and MRI Gas Ventilation Imaging of the Lungs 14. Hyperpolarized Gas MRI of the Lung in Asthma 15. Oxygen-Enhanced MR Imaging for Lung: Basics and Clinical Applications 16. Brain Imaging Using Hyperpolarized Xenon MRI 17. Xenon Biosensor HyperCEST MRI 18. Pulmonary Imaging Using ¹⁹F MRI of Inert Fluorinated Gases 19. Surface Quadrupolar Relaxation (SQUARE) Contrast in Pulmonary MRI With Hyperpolarized ⁸³Kr 20. Overview & Future Directions