Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.

Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.

Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspectivePromotes crosstalk between basic sciences and their applications in medicineProvides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principlesIntegrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

1. Dynamics and function of DNA methylation during development
2. Histone modifications in pluripotency and differentiation
3. ATP-dependent Chromatin remodelling: from early development to cancer
4. Regulation of cellular identity by Polycomb and Trithorax proteins
5. Crosstalk between chromatin marks at regulatory elements
6. Chromatin modifications and transcriptional noise in cell fate decision
7. Chromatin dynamics during the cell cycle
8. Chromatin dynamics and DNA repair
9. Epigenetic regulation of replication and replication timing
10. Interplay between chromatin and splicing
11. Nuclear lipids and the regulation of chromatin
12. Nuclear architecture and epigenetic memories: Heterochromatin formation in development, senescence and cancer
13.  Noncoding RNAs and the third dimension of the epigenome
14.  Epigenetic control of the nucleolus
15. X chromosome inactivation in 3D
16. Telomere maintenance in the dynamic nuclear architecture
17. Interaction between cellular metabolic states and chromatin dynamics
18. Circadian plasticity of the epigenome
19. The epigenome at the gene-environment interface in complex disease